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Biomarkers identified through integrated bioinformatics approaches often exhibit limited temporal stability during sepsis progression. To address this...

Post-hemorrhagic hydrocephalus (PHH) necessitates surgical intervention to alleviate symptoms and prevent neurological sequelae. The role of inflammat...

Cord blood (CB)-derived chimeric antigen receptor (CAR) natural killer (NK) cells have demonstrated significant antitumor efficacy. We recently report...

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Allergic Fungal Rhinosinusitis (AFRS) is a chronic inflammatory condition characterized by a strong Th2 immune response. The role of genetic factors,...

Tumors with low expression of interferon-stimulated genes (ISG) and antigen presentation (AP) genes respond relatively poorly to current immunotherapi...

Respiratory viral infections establish tissue-resident memory T cells (TRM) in the lung, which provide optimal protection against subsequent infection...

The Nonclinical Translation Working Group of the IQ Drug-Induced Liver Injury (DILI) Consortium conducted two surveys in 2023 and 2017 to canvas membe...

The COVID-19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primar...

Mycobacterium haemophilum is a nontuberculous mycobacterium that predominantly causes disease in immunocompromised patients. Due to some similarities,...

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Minimising the foreign body response (FBR) to implants remains an unmet clinical challenge. The mechanical properties of biomaterials, particularly st...

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Osteoarthritis (OA) remains a major clinical challenge due to the lack of effective treatments capable of halting disease progression. Chronic synovia...

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Hydrogel microspheres (HMs) are versatile biomaterials with biocompatibility and controlled release properties, widely applied in drug delivery, cell...

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Bacterial infections represent a global challenge, posing a significant burden and life-threatening complications. Traditional therapeutic regimens, p...

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We study the long time behaviour of a non-local parabolic integro-differential equation modelling the evolutionary dynamics of a phenotypically-struct...

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While the development and use of Artificial Intelligence (AI) in health care have literally exploded in recent years, general practitioners (GPs) cont...

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Enhanced recovery after surgery (ERAS) protocols emphasize multimodal interventions to accelerate recovery. Minimally invasive elective robotic-assist...

To evaluate the quality of domestic and international clinical practice guidelines for adult high-grade glioma, provide evidence-based recommendations...

Higher phytoglycogen in Su1-based sweetcorn kernels have created a niche market in Europe and Americas due to its distinct aroma, flavour and tenderne...

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mRNA therapeutics are emerging as a revolutionary therapeutic modality, providing a versatile platform for the treatment and prevention of a broad spe...

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Ectopic pregnancy is a gynecological emergency that can be life-threatening if not diagnosed and treated promptly. This review discusses therapeutic o...

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BPC 157, known as the "Body Protection Compound", is a pentadecapeptide isolated from human gastric juice that demonstrated its pleiotropic beneficial...

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We focused on the relationship of 0.5% tetracaine- and 0.4% oxybuprocaine-induced corneal anesthesia in rats, and pentadecapeptide BPC 157 (0.4 µg/eye...

In the suited rat-models, we focused on the stable pentadecapeptide BPC 157, L-NAME, NOS-inhibitor, and L-arginine, NOS-substrate, relation, the effec...

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There is a current need for a therapy that can alleviate the social and economic burden that presents itself with debilitating and recurring musculosk...

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Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti-ulcer peptide that heals different or...

Striae distensae (SD) are associated with negative psychosocial effects. Improvements have been shown with non-ablative fractional lasers (NAFL). Topi...

Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is considered as one of the hallmarks of Alzheimer's disease (AD). The...

Primary cutaneous T cell lymphomas (CTCL) are a heterogeneous group of rare lymphoproliferative disorders originating in the skin. Extracorporeal phot...

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Patients with Nagashima-type palmoplantar keratoderma (NPPK) experience progressive, painful hyperkeratosis and fissuring of palms and soles that limi...

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Bladder cancer (BCa) remains a significant global health challenge with rising incidence and suboptimal outcomes in advanced stages. Although immunoth...

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TGF-β/Smad3 signaling is a key pathway leading to the cell death and renal fibrosis. Here we report a new mechanism through which Smad3 mediates renal...

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Androgenetic alopecia (AGA) is a condition of scalp hair growth characterized by progressive miniaturization of hair follicles and a reduction in the...

BackgroundThis study evaluated the long-term safety, tolerability and effectiveness of rimegepant, 75 mg orally disintegrating tablet, for the acute t...

Glioblastoma (GBM) has proved difficult to treat, and there is dire need for more effective therapies. In a single arm phase IIa trial (NCT02455557),...

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Large-scale genomics efforts led to the identification of an increasing number of mutations in various cancers. However, the functional role of a vast...

The immune system mediates pain perception in preclinical models. Yet, the role of the immune system in transition to a chronic pain state in humans r...

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Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by tense blisters and itchy erythema, predominantly affecting elderly indivi...

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Feline hepatozoonosis, due to Hepatozoon felis, has been recently reported in wild cats from Central Europe. At the same time, only two isolated cases...

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Allogeneic hematopoietic cell transplantation (allo-HCT) remains a key treatment for patients with chronic myeloid leukemia (CML) in blast phase (CML-...

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Polygenic Scores (PGSs) summarize an individual's genetic propensity for a given trait. Bayesian methods, which improve the prediction accuracy of PGS...

CRISPR-based diagnostics have emerged as a promising tool for fast, accurate and portable pathogen detection. There has been rapid progress in pre-amp...

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The majority of patients with chronic tic disorders suffer from psychiatric comorbidities, most frequently attention-deficit/hyperactivity disorder (A...

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The global replacement of Bisphenol A (BPA) with structurally similar yet understudied analogues demands precise biomonitoring tools to assess human e...

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This study investigated the efficacy of the One Strain Multiple Compounds (OSMAC) strategy in enhancing the anti-cancer potential of metabolites deriv...

Adoptive cell therapy (ACT) with T cells targeting Kirsten rat sarcoma (KRAS) neoantigens can drive anti-tumor immunity but has so far been focused on...

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Highland barley bran (HBB), a by-product of milling, is rich in bioactive compounds with significant health benefits. This study explores the bioavail...

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