Adipokines play fundamental roles in regulating inflammatory responses. Patients with COVID-19 and mucormycosis suffer from inflammatory responses lea...

Tumor necrosis factor α (TNFα) maintains homeostasis through promoting cell survival or cell death; however, how this process is regulated by metaboli...

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Diabetic foot ulcers (DFUs) represent a clinically burdensome and pathophysiologically distinct complication of diabetes mellitus, marked by persisten...

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Heart failure (HF) and atherosclerosis represent two major cardiovascular diseases that are intricately linked, both contributing significantly to glo...

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Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated efficacy for weight loss and glycemic control in patients with obesity and t...

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Metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis poses a significant clinical challenge, especially given its strong association...

Semaglutide (Ozempic®), administered as a weekly subcutaneous injection up to 1.0 mg, holds a privileged place in the international guidelines for the...

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The approvals of semaglutide and tirzepatide have set new benchmarks in the treatment of type 2 diabetes and obesity. Building on their success, novel...

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Semaglutide is a glucagon-like peptide-1 receptor agonist, approved and currently actively used worldwide for the treatment of type 2 diabetes mellitu...

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This systematic review and network meta-analysis evaluated the efficacy and safety of obesity management medications (OMMs) in terms of reducing body...

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Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and discoid lupus erythematosus (DLE) are lymphocytic cicatricial alopecias causing irrev...

Diabetic wounds not only suffer from vascular and nerve damage, but also face the severe challenge of impaired stem cell activity. In recent years, al...

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Induced pluripotent stem cells (iPSCs) derived from patients with premature aging disorders are widely regarded as a foundation for both the study of...

Heart failure with preserved ejection fraction (HFpEF) is becoming increasingly prevalent in aging societies. A recent multicenter cohort study in Jap...

Aging bridges worldwide face growing safety challenges due to extended service life and environmental stressors. However, most existing studies lack a...

The central nervous system is a key regulator of energy and glucose homeostasis, integrating peripheral signals such as hormones and nutrients to main...

Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide, with treatment resistance posing a significant clinical...

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Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), with no a...

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The purpose of this study is to describe the changes in the age-standardized prevalence rate, incidence rate, and years lived with disability (YLDs) r...

Congenital hyperinsulinism (HI) is a disorder of insulin regulation that results in hypoketotic hypoglycemia and is associated with a high risk of neu...

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Sarcopenia, commonly observed in diabetes, is characterized by reduced muscle mass and function. However, the relationship between muscle oxygen satur...

Wolfram Syndrome Type 1 (WS1) is a rare neurodegenerative disorder characterized by diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA...

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Introduction Insulin resistance (IR) and impaired beta-cell function (BCF) are central to type 2 diabetes (T2D) pathogenesis and influence lipid metab...

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Glucagon-like peptide-1 (GLP-1) is a gut-derived hormone essential for maintaining glucose homeostasis through multiple physiological pathways: trigge...

Not required for Clinical Vignette.

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Obesity is a major driver of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associat...

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Body protection compound-157 (BPC-157) is a naturally occurring gastric peptide that promotes mucosal integrity and homeostasis. Preclinical studies s...

High-level athletes and bodybuilders are constantly seeking novel therapies to enhance recovery and expedite return from injury-injectable peptides ar...

Body-protective compound (BPC) 157 demonstrates protective effects against damage to various organs and tissues. For future clinical applications, we...

Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal ca...

The skincare market, which is projected to be worth over $180 billion by 2024, has experienced a recent rise in formulations utilizing peptides. These...

Malaria remains a global health crisis, with resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the limitatio...

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Midnolin has emerged as a versatile protein involved in gene regulation, metabolism and disease. It controls Early Response Genes by promoting their u...

To examine the central sensitization and its determinants in systemic lupus erythematosus (SLE) and compare it with psoriatic arthritis (PsA) and heal...

In addition to its coverage of the noncoding genome, whole-genome sequencing (WGS) may better capture the coding genome than exome sequencing. Here we...

Bio-accumulation of endocrine-disrupting chemicals (EDCs) in human body may result in various adverse health effects. This study measured the levels o...

Traditional strategies for the metabolic profiling of doping are limited by the unpredictable metabolic pathways and the numerous proportions of backg...

Monocrotaline selectively injures the lung's vascular endothelium and induces pulmonary arterial hypertension. The stable gastric pentadecapeptide BPC...

A new peptide, body protecting compound (BPC), BPC 157, and a variant of mechano-growth factor (MGF), MGF R23H, were identified in confiscated vials....

Apart from becaplermin (recombinant human platelet-derived growth factor homodimer of B chains, PDGF-BB), for the treatment of lower extremity diabeti...