Striae distensae (SD) are associated with negative psychosocial effects. Improvements have been shown with non-ablative fractional lasers (NAFL). Topical peptides have also been effective in cutaneous rejuvenation; however, no studies have examined combination therapy for striae. Our study evaluated the efficacy and safety of a peri-procedural tripeptide/hexapeptide serum as an adjunct to 1540 nm NAFL for the treatment of SD in 10 patients. All patients reported subjective improvement. The addition of tripeptide/hexapep-tide serum increased the objective improvement, reduced the incidence of post-inflammatory hyperpigmentation, and increased patient satisfaction.