Regenerative MedicineOpen AccessPeer Reviewed
BPC-157 promotes tissue regeneration and wound healing through modulation of growth factor pathways: A preclinical study
Authors
Dr. Ana KovačevićUniversity of Zagreb School of Medicine
Prof. Rajesh PatelMayo Clinic
Regenerative Medicine
Future Medicine LtdIF: 4.2
Published
Feb 08, 2024
Metrics
43 citations•Altmetric: 67
Abstract
Body Protection Compound-157 (BPC-157) is a pentadecapeptide with demonstrated cytoprotective and regenerative properties. This study investigates the molecular mechanisms underlying BPC-157's therapeutic effects on wound healing and tissue repair. Using both in vitro and in vivo models, we demonstrate that BPC-157 significantly accelerates wound closure, enhances angiogenesis, and promotes collagen synthesis through upregulation of VEGF, FGF, and TGF-β pathways.
Keywords
BPC-157wound healingtissue regenerationangiogenesisgrowth factors
Funding
Croatian Science Foundation
Grant: IP-2022-02-1234
Croatia
Article Metrics
Citations43
Altmetric Score67
Impact Factor4.2
Sourcepubmed